The smart Trick of ceesdekker That No One is Discussing
The smart Trick of ceesdekker That No One is Discussing
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Utilizing single-molecule optical and AFM imaging and pressure-spectroscopy tactics, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our exploration passions consist of:
Human Rad51 filaments on double- and single-stranded DNA: correlating standard and irregular types with recombination purpose.
Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2010, formulated a completely new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by way of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-point out nanopores
Our analysis ranges from your biophysics of DNA to synthetic cells and beyond. Remember to take a look beneath on the spectrum of our existing assignments.
‘At the beginning we looked at biological devices with a Bodily watch and acted on the basis in the instruments we realized. It took a few years ahead of we begun working a lot more on the large Organic challenges. I then started to get in touch with it nanobiology, a phrase that didn't exist at enough time.
Nanopores stand for a sublime and multipurpose Software to evaluate one molecules. We research novel detection modes with solid-state nanopores as well as various methods to measure proteins with nanopores. Projects encompass the subsequent:
Being familiar with essential procedures regulating the spatial and dynamic organisation of the DNA in Stay cells.
At this time, we also realized that it ought to be probable to work with an individual semiconducting carbon nanotube to generate a transistor — and we set out to make it. We stretched person semiconducting nanotubes throughout metallic electrodes and used the fundamental silicon substrate being a gate electrode, setting up the basic a few-terminal structure of the subject-result transistor (Fig.
Illustration (4) of bending configurations in 3D simulations of DNA ceesdekker.net rods on nanopores. A portion of the membrane is shown in gray, the rim on the pore is highlighted in crimson, along with a 3D rendering of the movement on the DNA rod is shown.
Afterwards we spoke yet again briefly because Dekker felt that our discussion of his faith speedily turned purely philosophical, Whilst Additionally, it concretely aids him in his get the job done.
Developments in nanotechnology within the 1990s produced creating electronic units from solitary molecules a likelihood. Cees Dekker recounts how his crew developed a area-temperature transistor determined by an individual carbon nanotube.
The biophysicist from Delft – who has become The most cited researchers within the Netherlands For many years – takes his obligation to lead to your rationalization and popularisation of his function within the border of physics and biology extremely very seriously and on a regular basis seems within the media; Otherwise to look at his operate, then about the relationship concerning science and his Christian religion.